Ketoconazole & zinc pyrithione lotion

Learn more Pharmacodynamics Ketoconazole, similarly to other azole antifungals, is a fungistatic agent which causes growth arrest in fungal cells thereby preventing growth and spread of the fungus throughout the body. Mechanism of action Ketoconazole interacts with 14-α-sterol demethylase, a cytochrome P-450 enzyme necessary for the conversion of lanosterol to ergosterol. Target Actions Organism A antagonist Humans U Not Available Humans Absorption Ketoconazole requires an acidic environment to become soluble in water. Volume of distribution Ketoconazole has an estimated volume of distribution of 25.41 L or 0.36 L/kg. Protein binding Ketoconazole is approximately 84% bound to plasma albumin with another 15% associated with blood cells for a total of 99% binding within the plasma. Metabolism The major metabolite of ketoconazole appears to be M2, an end product resulting from oxidation of the imidazole moiety. Hover over products below to view reaction partners • Ketoconazole • Route of elimination Only 2-4% of the ketoconazole dose is eliminated unchanged in the urine. Half-life Ketoconazole experiences biphasic elimination with the first phase having a half-life of 2 hours and a terminal half life of 8 hours. Clearance Ketoconazole has an estimated clearance of 8.66 L/h. Adverse Effects The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ketoconazole. The metabolism of Abacavir can be decreased when combined with Ketoconazole. The serum concentration o...