Carbetocin vs oxytocin

• Home Currently selected • Articles & Issues • Latest Articles • Current Issue • Previous Issues • Consensus and Guidelines • Collections • Preeclampsia • Gestational Diabetes Mellitus • Twins • Preterm Birth • Obstetric Hemorrhage • Infectious Diseases and Sexual Transmitted Diseases • Placenta Accreta Spectrum Disorders • Prenatal Diagnosis and Screening • Fetal Growth Restriction • Cesarean Section • Imaging Medicine • Rare Diseases • Others • For Authors • Submit Your Manuscript • Instructions for Authors • Language Editing Services • Editorial, Legal, and Ethical Policies • Multimedia • Video Gallery • Journal Info • About the Journal • Editorial Board • Open Access • Advertising • Reprints • Rights and Permissions • News • Call for Reviewers • Call for Papers • MFM Accepted in Scopus Indexing • Updates on Citations Received • Hiring: English Editor (part-time), Maternal-Fetal Medicine Original Article Intravenous Administration of Carbetocin Versus Oxytocin for Preventing Postpartum Hemorrhage After Vaginal Delivery in High Risk Women: A Double-blind, Randomized Controlled Trial Liu, Hua; Xu, Xiu-Yun; Gu, Ning; Ye, Xiao-Dong; Wang, Zhi-Qun; Hu, Ya-Li; Dai, Yi-Min ∗ Editor(s): Li, Yan-Li ; Pan, Yang Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China. ∗Corresponding author: Prof. Yi-Min Dai, Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical Sc...

Background The World Health Organization (WHO) recommends oxytocin as the drug of choice for postpartum hemorrhage (PPH) prevention. However, the WHO has also recently considered carbetocin for PPH prevention, but only if carbetocin were a cost-effective choice in the country. Consequently, we determined the cost-effectiveness and budgetary impact of carbetocin against oxytocin in the Philippines. Methods A cost-utility analysis using a decision tree was done to compare the costs and outcomes of carbetocin with oxytocin for PPH prophylaxis among women undergoing either vaginal delivery (VD) or cesarean section (CS) in a six-week time horizon using a societal perspective. One-way and probabilistic sensitivity analyses were applied to investigate parameter uncertainties. Additionally, budget impact analysis was conducted using a governmental perspective. Results were presented as incremental cost-effectiveness ratio (ICER) using a 2895 United States dollar (USD) per quality adjusted life year (QALY) gained as the ceiling threshold in the Philippines. Results Carbetocin was not cost-effective given the listed price of carbetocin at 18 USD. Given a societal perspective, the ICER values of 13,187 USD and over 40,000 USD per QALY gained were derived for CS and VD, respectively. Moreover, the ICER values were sensitive to the risk ratio of carbetocin versus oxytocin and carbetocin price. On budget impact, the five-year total budget impact of a drug mix of carbetocin and oxytocin ...

• Research • • 12 June 2023 Comparative study between oxytocin and combination of tranexamic acid and ethamsylate in reducing intra-operative bleeding during emergency and elective cesarean section after 38 weeks of normal pregnancy • • • • • • • • • • • •  ORCID: orcid.org/0000-0001-8472-269X • • • … • Show authors BMC Pregnancy and Childbirth volume 23, Article number: 433 ( 2023) Objective Cesarean Section (CS) is associated with an increased risk of hemorrhage. Many drugs are used to decrease this risk. We aim to compare the combination of ethamsylate and tranexamic acid, oxytocin, and placebo in women undergoing CS. Methods We conducted a double-blinded, randomized, placebo-controlled trial between October and December 2020 in four university hospitals in Egypt. The study included all pregnant women in labor without any complications who accepted to participate in the study between October and December 2020. The participants were divided into three groups. The subjects were randomly allocated to receive either oxytocin (30 IU in 500 ml normal saline during cesarean section), combined one gram of tranexamic acid with 250 mg of ethamsylate once before skin incision, or distilled water. Our main outcome was the amount of blood loss during the operation. The secondary outcomes were the need for blood transfusion, hemoglobin and hematocrit changes, hospital stay, operative complications, and the need for a hysterectomy. The one-way ANCOVA test was used to compare ...